
Yes, Nicole Kidman as a tranny (typecasting if I ever saw it) and Gwyneth Paltrow as his/her wife. Charlize Theron was originally going to play the wife, but she must've realized that playing anything opposite Kidman as a tranny had second-fiddle written all over it.
Paltrow, on the other hand, doesn't mind playing second-fiddle to Nicole Kidman. Or fourth-fiddle to Robert Downey, Mickey Rourke and Scarlett Johansson as she will be doing in Iron Man 2.
One thing's for sure: when Gwyneth shows up on the set, she will have a clean colon.